Clinical Program Director

What is Motif?

Motif is a medical device startup based in Houston, Texas. We are designing and developing minimally invasive electronic solutions for serious mental health conditions. Powered by our patent-pending methods for wireless power and data transmission, our goal is to create the smallest implantable brain stimulator to treat people with mental health disorders.

We are an early-stage startup with funding from venture capital firms, grants, and private angel and founder investments.

Motif's technology stack consists of a small implant that is wirelessly powered via magnetic fields from an external wearable transmitter, configured and controlled from a programming interface. It delivers novel stimulation therapy to cortical targets and will evolve to record biomarkers of symptoms, disease state, and therapy response.

Where are we going?

We are currently completing the development of our first minimally invasive neural stimulation system and preparing for future versions with additional functionality based on our platform technology.

About the Job

We are seeking an experienced Clinical Program Director to design and execute strategies that generate high-quality evidence for regulatory approval, product validation, and therapy adoption. You'll have the rare opportunity to shape pivotal clinical programs, influence product direction, and leave your mark on a company at the forefront of mental health innovation.

You'll gain experience shaping pivotal clinical programs, learn from cross-functional experts in Leadership, R&D, Regulatory, and Biostatistics, and collaborate with CRO partners and Key Opinion Leaders to drive advancements in patient care.

Job Location: Remote, with travel to Houston, Texas and clinical sites several times per year

Does this sound like you?

• You want to shape the future of mental healthcare by leading clinical programs that bring groundbreaking technology to patients.
• You thrive on understanding novel therapies and driving them through the clinical evidence pathway.
• You excel at designing and executing studies that test hypotheses, overcome challenges, and deliver results on time.
• You believe that transparency and collaboration are essential to clinical program success.
  
  

If yes, you'll love working at Motif — we are a team of passionate, dedicated people building something extraordinary in neurotechnology, clinical product development, and patient-first innovation. We move fast, work collaboratively, and value the autonomy and ownership that comes with a high-growth environment.

In this role, you will lead the following functional areas:

Clinical Strategy & Evidence Planning

• Develop and maintain global clinical evidence plans aligned with therapy objectives, product development milestones, and regulatory requirements.
• Create and manage multi-year evidence roadmaps addressing both pre-market and post-market study needs.
• Design clinical studies that support product claims, regulatory submissions, and long-term therapy adoption.
  
  

Study Execution & Contractor Management

• Lead execution of industry-sponsored clinical trials in collaboration with CROs, specialized vendors, and consultants.
• Oversee study design, site strategy, patient recruitment, and data quality to meet regulatory and product performance goals.
• Manage timelines, budgets, and operational risks with proactive mitigation strategies.
• Ensure studies are delivered on time, within budget, and in compliance with GCP, ISO 14155, and applicable regulations.
  
  

Cross-Functional Collaboration

• Work closely with Leadership, Market Access, Regulatory, R&D teams to ensure study design supports product development and approval strategies.
• Collaborate with clinical scientists and biostatisticians on endpoint selection, statistical analysis plans, and data interpretation.
  
  

KOL Development & Management

• Identify, engage, and develop relationships with global and regional KOLs to guide clinical strategy and enhance program credibility.
• Partner with KOLs to refine study design, endpoints, and recruitment strategies.
• Foster long-term KOL relationships to support ongoing evidence generation, scientific exchange, and therapy adoption.
  
  

To be considered, you will need:

• Bachelor's degree in engineering, science, health science, nursing, or related field.
• 10+ years of experience leading clinical research programs in the medical device industry, including study management.
• Proven success designing and executing industry-sponsored clinical trials in implantable medical devices or interventional psychiatry that achieved regulatory or launch milestones.
• Strong experience in identification, development, and management of medical professionals and KOLs.
• Experience managing CRO and multiple vendors.
• Familiarity with device regulations, GCP, and ISO 14155.
  
  

Benefits*

• Medical, dental, and vision insurance for you and your dependents
• Participation in our 401k plan
• Unlimited PTO
• The chance to work with an incredible group of people working towards a common goal for a better future
  
  

We envision a world where everyone with a mental health disorder can get well and stay well, regardless of who you are, where you live, or how much money you make, and we are excited to build that future with you.

Let's use our powers for good.

Motif Neurotech is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran status, disability status, or any other protected class status.

• for regular full-time, exempt, salaried US employees